TARGETED RESEARCH AREAS
Enduring Hearts funds innovative, cutting-edge pediatric heart transplant research targeted but not limited to the following focal areas:
Identification of early, onset of rejection through the further development of accurate non-invasive methods and strategies to detect acute cellular and antibody-mediated rejection and cardiac allograft vasculopathy.
Click here to view our transplant longevity targeted research!
Development of new technologies or technological applications that would improve the care and outcomes of transplant recipients.
Click here to view our technology application targeted research!
Research and development of novel immunotherapies, identification of novel targets, improving the side-effect profiles of these agents, as well as better monitoring and measurement of immunosuppression.
Click here to view our transplant immunology targeted research!
Strategies and innovations that would allow better organ matching and allocation.
Click here to view our organ matching targeted research projects!
Development of evidence for pediatric heart recipient nutrition and exercise guidelines that improve the long-term outcomes of pediatric heart transplant recipients.
Click here to view our nutrition and exercise physiology targeted research projects!
Development of evidence-based strategies to improve adherent behaviors, including medication compliance, especially in adolescent recipients.
Click here to view our medication compliance targeted research projects!
Improving patient and family education, related to transplantation.
Click here to view our education targeted research projects!
Utilizing the latest innovations or new technologies that would improve outcomes for children leading up to and after they receive a heart transplant.
Click here to view our pre-transplant strategy targeted research projects!
Past Research Projects
Transplant Longevity
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on transplant longevity, we have successfully been able to make an impact on the lives of children living with a new heart. When Enduring Hearts was founded, the average transplant lasted just 12 years, now we have successfully been able to impact research here, where the average transplant now lasts 17 years! Our goal is to one day make the first transplant last a lifetime!
- Improving Late Survival after Pediatric Heart Transplant through Improved Understanding of Post-Tx Myocardial Fibrosis
- 2D Speckle Tracking Echocardiography for Non-Invasive Surveillance of Rejection and Coronary Disease in Pediatric Heart Transplant Recipients
- Cardiac MRI Assessment of Rejection and Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients
- MicroRNA Biomarkers of Allograft Rejection in Cardiac Transplantation
- Cell-free DNA for the Diagnosis of Rejection After Heart Transplantation
- Antibody Mediated Allograft Injury Following Pediatric Heart Transplantation: Mechanistic Insights and Predictive Modeling
- Developing a Comprehensive Biomedical Imaging Informatics Tool for Precision Care of Pediatric Heart Transplant Patients
- Integrating Multi-parametric Echocardiography with Computer Assisted Analysis in Detection for Early Allograft Rejection in Pediatric Heart Transplant Recipients: A Pilot Prospective Multi-center Study
- The Causal Role of Axl in the Acceleration of Cardiac Allograft Vasculopathy
- Circulating microRNAs: Biomarker for Acute Graft Rejection in Pediatric Heart Transplant Recipients
- Plasma Induced Transcription Analysis in Pediatric Heart Transplantation as an Assessment of Rejection
- CD122 Targeted Theragnostic for Detection and Prevention of Heart Transplant Rejection
- Human Cell-Derived model of Endomyocardial Tissue Injury and Cardiac Allograft Vasculopathy
Technology Application
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on technology applications, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
Transplant Immunology
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on transplant immunology, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
- Chimerism of Cardiac Myocytes in Transplanted Heart
- Validation of a Novel Non-Invasive Assay for the Detection of Heart Rejection
- Contribution of Innate-Like B Cells to Human Cardiac Allograft Vasculopathy (CAV)
- Novel Tolerogenic CD34/MSC Di-Chimeric Cell Therapy in Vascularized Composite Allograft and Heart Transplant
- Enduring Hearts Pediatric Cardiac Research Fund
- Regulating Glycosaminoglycans in Transplant Vascular Disease and Chronic Rejection
- Roles of Cardiac and Hepatic Macrophage Subsets in Immune Tolerance
- En Bloc Donor Thymus Co-transplantation to Achieve Tolerance in Pediatric Heart Recipients
- Defining Tissue-Resident Endothelial Heterogeneity and Plasticity after Inflammatory Insult in Solid Organ Transplantation
- Functional Consequences of Antigen Specificity in CMV-Responsive T-cells
- Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy
- Endothelial Barrier in Allograft Rejection and Tolerance
Organ Matching
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on organ matching, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
Nutrition and Exercise Physiology
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on nutrition and excercise, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
Medication Compliance
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on medication compliance, we have successfully been able to make an impact on the lives of children living with a new heart through developing better and more successful adherence practices in their lives. Our goal is to one day make a transplant last a lifetime!
Education
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on transplant education, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
Pre-Transplant Strategies
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on the importance of pre-transplant strategies, we have successfully been able to make an impact on the lives of children living with a new heart. Our goal is to one day make a transplant last a lifetime!
Other Funded Projects
To view more information about a research project, click the title to view the project page.
By funding life-saving research with a focus on pediatric heart transplantation, we have successfully been able to make an impact on the lives of children living with a new heart.
- Immunogenetic Markers of Extreme Clinical Phenotypes of Post Transplant Lymphoproliferative Disorder
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation
- The Role of Endogenous, Antigen-Specific, Auto- and Alloreactive Tregs in Transplantation Tolerance
- Strategies to Improve Early Injury and Promote Long Term Tolerance Post-Cardiac Transplants
- The Impact Of Fontan Circulatory Failure, Frailty, and Resilience on Heart Failure and Transplant Outcomes
- Can HLA Data be Used to Support Precision Medicine in Pediatric Heart Transplantation?
