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For Investigators

OUR FUNDING focus

1.1. Integrating accurate non-invasive surveillance methods, technologies and/or biomarkers for recipient care strategies
and EARLY identification of the onset of acute cellular rejection (ACR), antibody-mediated rejection (AMR) and/or
cardiac allograft vasculopathy (CAV).


1.2. Developing improved therapeutics and/or therapeutic strategies for acute cellular rejection (ACR), antibody-mediated
rejection (AMR) and/or cardiac allograft vasculopathy (CAV).


1.3. Developing novel immunotherapies, identification of novel targets for immunosuppression, improving methods for
monitoring and determining the optimal level of immunosuppression to prevent ACR, AMR, and/or CAV while
reducing/eliminating secondary conditions that may arise due to immunosuppression (e.g., renal; infectious).


1.4. Developing and validating experimental models to study the underlying mechanisms, therapies, and/or prevention of
CAV.


1.5. Developing more evidence-based person-centered post-transplant care guidelines, including nutrition and exercise
guidelines

2.1. Improving transitioning from pediatric to adult care/medication adherence.


2.2. Development of evidence-based tools for improving pediatric heart recipient and family education related to heart
transplantation.


2.3. Improving evidence-based diverse psycho-social support methods including technologies, hosted peer action groups,
virtual visit models and remote metrics.

3.1. Applying advanced data analytics to better integrate extracardiac and cardiovascular candidate risk factors including
degree of multiorgan dysfunction and frailty, race and ethnic group, and HLA and non-HLA sensitization.


3.2. Innovative strategies that would improve organ availability, matching, utilization, and allocation.

3.3. Pre-transplant modifications in donor heart immunogenicity.

3.4. Promotion of evidence-based optimization and standardization of pre-transplant protocols including donor selection and
management.

3.5. Pediatric scaled xenotransplantation and/or tissue engineering.

ENDURING HEARTS 2023 DIRECT GRANT

Additional weighting is afforded to the impact of a proposed research study as evidenced by its potential to translate within the next five years; directly involving pediatric heart transplant
recipients and/or their families; and its potential to promote equity as well as standardization of post-transplant care of pediatric heart recipients.

  1. Please send questions to: Grants@enduringhearts.org
 
SEE GRANT INSTRUCTIONS BELOW

Enduring Hearts Grant Process

 
IMPORTANT DEADLINES

Spring 2023

LOI Submission Deadline: April 10, 2023

Full Grant Proposal: May 8, 2023

Fall 2023

LOI Submission Deadline: September 11, 2023

Full Grant Proposal: October 9, 2023

ENDURING HEARTS/ISHLT TRANSPLANT LONGEVITY RESEARCH AWARD

Enduring Hearts partners with ISHLT to fully fund a transplant longevity award every two years. The purpose of the Award is to further the scientific understanding of the determinants of pediatric transplant heart longevity and thereby improve the quality and duration of life. The awardee will be announced at the ISHLT conference in Denver, Colorado in April 2023.

 

Click here to submit an application

 

Important deadlines

Application Deadline: January 16, 2023

ENDURING hearts/ phts Investigator award 

The organizational goal of Enduring Hearts is to promote research to improve longevity of, and quality of life for, pediatric heart transplant recipients, and ultimately reduce and eliminate pediatric heart disease. To date, Enduring Hearts has funded 1 to 2-year investigator-originated research projects consistent with these goals and below identified areas of scientific interest. Investigators must hold a PhD, MD, DNP or BSN and have an appointment with a Pediatric Heart Transplant Center or University. It is the expressed intent of Enduring Hearts to form collaborations with PHTS to achieve mutually shared goals.

The purpose of the collaboration is to further the scientific understanding of the determinants of longevity of transplanted pediatric recipients and their transplanted heart to improve the quality and duration of life.

2023 Application Submission Dates:

Spring

February 1, 2023 – February 28, 2023

Fall

October 1, 2023 – October 31, 2023

 

CLICK HERE TO START APPLICATION PROCESS

2022 award Recipients 

Dipankar Gupta, MD

University of Florida


Abstract: Use Of Donor Hearts With Low Ejection Fraction In Pediatric Heart Transplantation: A PHTS Analysis (ISHLT 2022)

Madeleine Townsend, MD

University of Alberta (UOA)

 

 Abstract: Statin Use in Pediatric Heart Transplantation Recipients in the Current Era (ISHLT 2023)

Irene Lytrivi Headshot

Irene Lytrivi, MD

Columbia University – Morgan Stanley Children’s Hospital of New York Presbyterian (CPM)


Abstract: Contemporary outcomes and management strategies of pediatric cardiac transplantation with a positive retrospective HLA crossmatch (AHA 2022)

For Investigators 2

ENDURING HEARTS Partners with AHA to fund pediatric heart Transplant research

Check back here for future award information or on social media.

We are excited to announce the first two awardees of the $3M joint research collaboration between Enduring Hearts and AHA.
Congratulations
Dr. Christopher Almond, Dr. Kevin Daly and Meghna Patel for receiving funding for “Clinical Ancillary Study to the TEAMMATE trial”
Dr. James Martin, Dr. Diwakar Turaga, and Dr.Iki Adachi on the selection of their study “Early Detection of Cardiac  Allograft Vasculopathy in Post-Transplant Hearts via Single-Cell Genomics”
https://newsroom.heart.org/news/scientists-in-california-texas-to-study-ways-to-help-children-receiving-heart-transplants

NEW ENDURING HEARTS AND ADDITIONAL VENTURES GRANT ANNOUNCEMENT

Enduring Hearts in partnership with Additional Ventures is announcing new funding to stimulate innovative research focusing on identifying, reducing and eliminating pre and post-transplant risk factors that affect outcomes of children born with complex congenital heart disease including single ventricle heart defects.

Congratulations to Kurt Schumacher, MD MS & Melissa Cousino, PhD of the University of Michigan as well as David Rosenthal, MD of Stanford University on being selected as recipients of this grant! 

Click here for more information or to review the RFP.

For questions or to learn more about this grant, please contact grants@enduringhearts.org

Please fill out the form below to sign up!